The Pluses (C-C-A-P)

 The Pluses, also known as CCAP, is an acronym that stands for Complete, Consistent, Accurate, and Permanent. It is an extension of the ALCOA and ALCOA+ data integrity principles, and it adds four additional criteria for ensuring data quality and integrity.

  1. Complete: Data should be complete, with no missing or omitted information. All relevant data should be recorded and included in the documentation.

  2. Consistent: Data should be consistent across all records and documentation, with no conflicting or contradictory information.

  3. Accurate: Data should be accurate, with no errors, mistakes, or misinterpretations.

  4. Permanent: Data should be maintained permanently, with no unauthorized or unintentional deletion, alteration, or modification.

The Pluses, along with ALCOA and ALCOA+, are used as a framework for ensuring data integrity in regulated industries such as pharmaceuticals, medical devices, and biotechnology. Adherence to these principles is critical for maintaining product quality, safety, and efficacy, and ensuring compliance with regulatory requirements.

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