What is Disintegration Test

 It is the time required for the Tablet / Capsule to break into particles, the disintegration test is a measure of the time required under a given set of conditions (Temperature) for a group of tablets/capsules to disintegrate into particles.

Cycle of shaft holding the tube basket limit is 29-32 cycles per minutes and distance covered by shaft basket is 50-60 mm and beaker temperature is 35 to 39 º C.

Disintegration is to be Performed to determine whether tablets or capsules disintegrate within the prescribed time when placed in a liquid medium at the experimental conditions.

3. What are the Disintegration Time of tablets :

  • Uncoated Tablet 15 min as per BP
  • Uncoated Tablet 30 min as per USP
  • Sugar Coated Tablet 60 min as per BP
  • Film Coated Tablet 30 min as per BP
  • Plain Coated Tablets DT in specific medium for 30 min as per USP
  • Enteric Coated Tablets DT in  simulated gastric fluid (0.1 M HCl) for 1 hr and then in simulated intestinal fluid (Phosphate buffer 6.8 pH) until disintegrate as per USP.
  • Dispersible Tablets 3 min ( 15- 25º C ) as per BP.
  • Effervescent Tablets 1 tablet in 200 mL water  for 5 min ( 15- 25º C )
  • as per BP
  • Buccal Tablets 4 hrs as per USP.
  • Soluble Tablets 3 min ( 15- 25º C ) as per BP.
  • Chewable Tablets are not require to comply with test

4. What are the Disintegration Time of capsules:

  • Gastro resistant capsule DT 2 hrs without disk in 0.1 M HCl  and phosphate buffer pH 6.8 for further  60 min as per BP.
  • Hard and Soft gelatin capsule DT 30 min as per BP & USP.

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